Side effects and drug Interactions.
A review paper on the safety and side effects of cannabiniods suggests that controlled cannabinoid administration is safe and non-toxic in humans and animals. It also does not induce changes in food intake; nor does it affect physiological parameters like heart rate, body temperature or blood pressure.
To see if CBD interacts with any of the medications that you are currently taking, click the button below and type “cannabidiol”, press enter and input the name of your medication.
There are very few known side effects of cannabinoids. The above review paper mentions the following as potential side effects.
Inhibition of Hepatic (Liver) Drug Metabolism.
To put this in perspective, eating a portion of grapefruit would have a similar effect on the P450 liver enzymes. Drug interactions should be viewed as a minor side effect of certain cannabinoids. As a precaution, if you are taking pharmaceutical drugs and plan to take cannabinoids, you should discuss any potential complications regarding reduced P450 enzyme activity with your doctor and/or pharmacist. In states that have legalized medical marijuana and hemp for many years, this potential interaction with the P450 enzyme has not proven to be clinically significant.
The only documented serious concern has been noted in epilepsy patients taking Clobazam, an anticonvulsant. A majority of these patients needed to have their dose of Clobazam reduced due to side effects. A 2015 report concluded that CBD is safe and effective for treatment of refractory epilepsy in patients receiving Clobazam, but emphasized the importance of monitoring blood levels of Clobazam in those patients using CBD.